This study was to explore whether adults with higher self-leadership have higher personal characteristics such as creative characters, psychological basic needs (i.e., autonomy, competence, and relatedness), intrinsic motivation, internal locus of control, and the Big 5 personality traits than those with lower self-leadership (SL). In this study, 495 adults were classified into two groups based on scores of the Revised Self-Leadership Questionnaire (RSLQ): high SL group and low SL group. Multivariate Analysis of Variance (MANOVA) was performed to investigate group differences on their personal characteristics. The findings showed that high SL group had higher personal characters, psychological basic needs, intrinsic motivation, internal locus of control, and four factors of the Big 5 personality traits (i.e., openness to experience, conscientiousness, extraversion, and agreeableness). A binary logistic regression analysis showed that 87.0 percent of the adults in this study were accurately classified as either high SL group or low SL group in respect to the relatedness, intrinsic motivation, and conscientiousness. Implications of the findings were discussed.