The purpose of the study is to estimate the latent classes of high school students’ satisfaction with career education and activities and individual and school factors determining these latent profiles. To this end, we used data from the first-wave survey of 10,345 students, including (5,444 male and 4,901 female students), of the Korean Education and Employment Panel II (KEEP II). Based on the latent profile modeling analysis, we identified three distinct latent classes of students' satisfaction with career education and activities. These classes were named ‘low-level satisfaction group,’ ‘intermediate-level satisfaction group,’ and ‘high-level satisfaction group.’ Second, multinominal logistic regression analysis revealed that gender, school life satisfaction, school facility satisfaction, classroom atmosphere, career competency, learning method, learning motivation, after-school program participation, and private tutoring were significant predictors of the latent profiles at the individual-level. Also, perception of school administration committees, career education, school environment and career guidance method were significant predictors of the latent profiles at the school-level. Implication of this study and recommendations for future research were also discussed.